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Under 21 coach David Platt has good memories of the Madejski Stadium - last time his side were in action there they thrashed Holland u21 4-0.
After Saturday's tough clash in Slovakia on Tuesday the u21 squad will turn their attention to Tuesday's game.
Platt's squad features potential stars of the future such as which features the likes of Joe Cole, Michael Carrick, Jermaine Pennant, Chris Kirkland and Jermain Defoe.
Speaking to readingfc.co.uk Platt said: "This is a very strong and exciting squad and I am looking forward to the two games coming up against Slovakia and then Macedonia at the Madejski Stadium."
Platt has been rocked by the news that Bolton superkid Kevin Nolan is likely to miss the game.
"At this stage it also looks unlikely that he'll be fit for Tuesday's game against Macedonia. It's a blow but we'll continue to monitor Kevin's progress in case his situation improves," confirmed Platt speaking to TheFA.com.
Meanwhile, Reading Football Club have confirmed that they have already sold over 8,000 tickets for next Tuesday's clash and are hoping for a bumper crowd to roar the young lions on to victory.
However, it looks unlikely that there will be a repeat of the sell out crowd last time England were in action at the Madejski Stadium.