MK won promotion from League 2 last season but lost their manager in the summer when Paul Ince moved to Blackburn to replace Mark Hughes.
Royals assistant boss told readingfc.co.uk, "We'll be taking 16 players and fielding a strong side.
"Kalifa Cisse and Ibrahima Sonko are due back next week, Andre Bikey is off with Cameroon at the Olympics and Brynjar Gunnarsson is injured.
"But other than that we'll be taking all the senior pros and it should be a good, tough game.