The midfielder is banned for one match after picking up his fifth booking of the season and could be replaced by Owain Tudur-Jones.
Boss Roberto Martinez made six changes for the FA Cup win over Histon in midweek and there is likely to be another overhaul of personnel for the return to league action.
Striker Jason Scotland, who has scored 11 goals this season in the league, started on the bench against Histon but will be reinstated to the Swans' attack.
Midfielder Nathan Dyer, on loan from Southampton until the end of the season, could make his first start for the club after consecutive substitute appearances.
Full-back Fede Bessone is fit again after struggling with a hamstring injury but he is unlikely to make the starting XI.
Reading manager Steve Coppell will be without defender Andre Bikey for the trip.
The Cameroon international is suspended after picking up five bookings this season and has also picked up ankle ligament damage which does not require surgery.
However Bikey has failed to oust Michael Duberry from the side since returning from an earlier suspension so Coppell will continue with the former Chelsea man alongside Ivar Ingimarsson.
Adam Federici will continue in goal but first-choice Marcus Hahnemann has returned to training after being out for six weeks with a calf injury.
Lita has spent most of the season on loan at Norwich and looked set to leave before his contract expires in the summer but has committed himself to the cause until at least the end of the season.