The fixture had been scheduled for Saturday 19th March, kick off 3pm, but has been moved so that ti can be screened live on Sky Sports.
With the Royals pushing for a top six spot, Steve Coppell's team will be aiming for for all three points when they travel to the Withdean Stadium for the encounter.
Reading v Brighton fixtures have proved to be exciting games over the past few years, with Reading triumphing by three goals to two last time the teams met back in August.
Dave Kitson, James Harper and Nicky Forster found the net on a sizzling Saturday afternoon in the sun on the season's opening day.
The upcoming game at the Withdean Stadium is sure to be another cracking encounter as it will be the first time that Royals manager Steve Coppell has returned to his former club since his departure for Reading fifteen months ago.
Coppell walked out on Brighton to move to the Mad Stad in much the same was as under-fire Hammers boss Alan Pardew did the dirty on Reading.
With the Seagulls managed my former Royals boss Mark McGhee extra spice is added to an already tasty fixture.
Meanwhile, Reading's game away at Wigan on 8th May, the last day of the season, has been moved to a 1pm kick off along with all the other Championship fixtures that day.