Karacan has missed the last three games through suspension but is available again.
Central defender Alex Pearce is still missing with a thigh injury, while Alex McCarthy will continue in goal.
The 21-year-old made his full debut for the Royals in the midweek win over Millwall as number one Adam Federici continues to be troubled with a knee injury.
The Australian was forced off with six minutes remaining of the 1-1 draw with Watford last Saturday so Mikkel Andersen will be on the bench as cover.
Striker Mathieu Manset is a doubt with a calf injury so former taxi driver Brett Williams could be on the bench again.
Source: PA
Source: PA