The Lions famously beat Reading to promotion to Division One two seasons ago, finishing as champions whilst the Royals could only manage third place and a Play-Off Final appearance.
Managed by disgraced former Reading boss Mark McGhee, the visit of Millwall is sure to provide a fiery atmosphere at the Madjeki Stadium tomorrow.
If the last meeting between the two sides is anything to go by it could be a cracker. Reading were unlucky to come away pointless, having been 4-0 down they managed to pull the game back to 4-3.
Alan Pardew could name an unchanged line-up from the one that defeated Bradford in midweek, Anthony Rougier isn't fit to return to the team after breaking his toe two weeks ago so he will again miss out.
Ricky Newman and Adie Williams could both be forced to miss the game through injury, however both are expected to be passed fit to play.
Nicky Shorey will continue at left-back after scoring his first ever career goal against the Bantams. Nicky Forster will retain his place up front despite missing numerous chances and a penalty during Tuesday's clash.
Under-fire Millwall boss Mark McGhee has had boardroom pressure for results eased following a 3-0 win against Derby and a 1-0 win at Hillsborough againt Sheffield Wednesday. Lions fans will be hoping for another good result tomorrow.
Steven Reid, who went to the World Cup with the Republic of Ireland, will miss the clash through injury despite returning to training this week.
Richard Sadlier and Tim Cahill will be joining Reid on the sidelines, they have alsoe been ruled out because of injury.
But Glen Johnson will be available for the Lions selection after returning from international duty with the England u19s.
Former Chelsea midfielder Dennis Wise, who was sensationally sacked by Leicester at the start of the season, is expected to play in the centre of midfield.
The controversial former England star was targeted by Alan Pardew but Millwall boss Mark McGhee won the race to sign him up on a free transfer.