Doyle - who has scored 18 goals this season, but only two in 2009 - missed the 2-2 draw with Blackpool on Monday after having an injection on his left knee but could return to freshen up the Royals attack.
Midfielders Kalifa Cisse (neck) and Brynjar Gunnarsson (hamstring) are both back in training after missing the trip to Bloomfield
Road and are expected to be in contention but James Harper remains sidelined.
Harper sat out both games over the Easter weekend with a groin problem and he is struggling to be fit enough to reappear this season.
The injuries in central midfield allowed youngster Jem Karacan to return at Blackpool and he scored to put himself in pole position to keep his place.
Right-back Liam Rosenior is back from suspension and came through 90 minutes for the reserves on Wednesday after having two broken bones in his hand pinned. He should return in place of Julian Kelly but Ivar Ingimarsson (knee) and skipper Graeme Murty (calf) are still out.
Barnsley manager Simon Davey will pick from a virtually full-strength squad - but could be tempted to make changes.
The Tykes have not won any of their last five league matches and face another nerve-jangling relegation fight following last week's
home defeat to Swansea.
Davey said: "We are fine ahead of the trip. We will go into the game with only Michael Coulson and Iain Hume missing from the squad."
Striker Michael Mifsud is hoping for a recall to the starting line-up at the Madejski Stadium and goalkeeper Luke Steele could come into the reckoning for a rare start.
Midfielder Hugo Colace and winger Martin Devaney are also pushing for returns as the Tykes chase their first away win since their South Yorkshire derby success at Sheffield Wednesday in mid-February.
Sporting Life