The club's top scorer this season could now be in contention for a role in Saturday's FA Cup game with Manchester United, whilst Brynjar Gunnarsson also returned from injury in the reserve game.
The victory over Spurs saw January signings Michael Duberry and Greg Halford make their first appearance for the club.
The goals came from Kitson 34, De La Cruz 63, Gunnarsson 68, Oster 75.
Teams
Reading (4-4-2): Federici; Halford, De La Cruz (c), Sodje, Duberry; Gunnarsson, Oster (Davies 80), Seol, Convey; Doyle (Cox 72), Kitson (Henry 72)
Subs: McCarthy, Bygrave
Tottenham (4-4-2): Cerny; Ifil, Daniels, Lee (c), Mills; Livermore (Archibald-Henville 68), O'Hara, Fraser-Allen (Pekhart HT), Hallfredsson; Barsham, Taarabt
Subs: Forecast, Hughton, Hutton